We correlate changes in phenotypic parameters such as cell organization, cell growth, and cell viability with disease- and therapy-relevant cellular signaling events in iPSC-derived cardiomyocytes. By adapting these approaches to other cell types, we advance the discovery of new therapeutic targets.
Utilizing cutting-edge biosensor-based approaches to generate individual signaling signatures.
Expertise in microscope-based imaging platforms and biochemical assays for in-depth cell function analysis.
We generate individual signaling signatures using biosensor-based approaches and biochemical assays that analyze cell function. Utilizing microscope-based imaging platforms, we examine downstream signaling of relevant disease targets in cardiomyocytes. By combining phenotypic responses with cellular signaling profiles, we advance our understanding of the maladaptive signaling landscape that arises in the development of heart failure.
Merging phenotypic changes with cellular signaling for comprehensive insights.
Real-time examination of signaling events using advanced microscopy.
We offer a range of services designed to uncover therapeutic targets and understand disease mechanisms through advanced cellular signaling analysis.
We utilize resonance energy transfer-based biosensors to interrogate extensive portions of the signaling signatures of specific G protein–coupled receptors (GPCRs). Our biosensor platform is available in adeno-associated viral formats for use in iPSC-derived cells. By determining which signaling pathways are modulated by dose-dependent activation of individual receptors, we provide detailed insights into cellular responses.
Our advanced imaging platforms allow for the examination of downstream signaling in cardiomyocytes. By visualizing signaling events in real time, we correlate these events with phenotypic changes such as cell organization, growth, and viability, enhancing our understanding of disease progression.
We offer functional assays to measure contractility and electrical properties of iPSC-derived cardiomyocytes. These platforms provide critical data on disease-relevant signaling and phenotypic events, facilitating the discovery of potential therapeutic interventions.
Our discovery services empower researchers and pharmaceutical companies to gain comprehensive insights into disease mechanisms and therapeutic targets. By integrating phenotypic responses with cellular signaling profiles, we accelerate the identification of maladaptive pathways and facilitate the development of effective treatments.
Combining phenotypic and signaling data for a holistic understanding of disease mechanisms.
Utilizing cutting-edge biosensor and imaging platforms to advance therapeutic discovery.
Contact us today to discover how we can support your innovative work with personalized solutions.
Empowering researchers to create and store iPSCs, unlocking the potential for groundbreaking treatments. Our innovations in stem cell science lay the foundation for future medical advancements.
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